RECOMENDAÇÕES DE TRIAGEM E MANEJO DAS ENDOCRINOPATIAS APÓS TRANSPLANTE DE CÉLULAS-TRONCO HEMATOPOIETICAS

Resumo

Endocrine disorders after hematopoietic stem cell transplantation result from the interaction between the underlying disease, host characteristics and treatment, including exposure to pre- and peri-transplant agents (chemotherapy and radiotherapy). In addition, post-transplantation factors, including graft-versus-host disease, and its treatment, especially glucocorticoids, also contribute to hormone deficiencies or endocrine disorders. Endocrinological alterations can be divided into six main groups: 1) Growth disorders; 2) Thyroid diseases; 3) Gonadal dysfunction; 4) Adrenal failure; 5) Osteometabolic disorders; 6) Obesity and metabolic syndrome. The purpose of this article is to update screening recommendations and management approaches for the various endocrine diseases, defining populations at risk, recommendations during follow-up, and treatment strategies, with attention to controversial issues.