RECOMMENDATIONS FOR SCREENING AND MANAGEMENT OF ENDOCRINOPATHIES AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION

Abstract

Endocrine disorders after hematopoietic stem cell transplantation result from the interaction between the underlying disease, host characteristics and treatment, including exposure to pre- and peri-transplant agents (chemotherapy and radiotherapy). In addition, post-transplantation factors, including graft-versus-host disease, and its treatment, especially glucocorticoids, also contribute to hormone deficiencies or endocrine disorders. Endocrinological alterations can be divided into six main groups: 1) Growth disorders; 2) Thyroid diseases; 3) Gonadal dysfunction; 4) Adrenal failure; 5) Osteometabolic disorders; 6) Obesity and metabolic syndrome. The purpose of this article is to update screening recommendations and management approaches for the various endocrine diseases, defining populations at risk, recommendations during follow-up, and treatment strategies, with attention to controversial issues.