Overall survival in patients with acute lymphoblastic leukemia treated with protocol CALGB 9511 at a tertiary hospital in the state of Ceará.

Authors

  • Paulo Henrique Mariano de Alencar Universidade Federal do Ceará
  • Fernando Barroso Duarte
  • Lívia Andrade Gurgel
  • Lara Facundo de Alencar Araripe
  • Hércules Amorim Mota Segundo
  • Ana Vitoria Magalhães Chaves

DOI:

https://doi.org/10.46765/2675-374X.2024v5n1p222

Abstract

Introduction: Acute lymphoblastic leukemia (ALL) is the most common neoplasm in childhood and has high survival rates. In adults, due to the biological characteristics of the disease and chemotherapy-related toxicity, survival is lower. CALGB 9511 is a chemotherapy protocol based on pediatric regimens with high remission rates after induction. Objectives: To evaluate the survival of patients with ALL undergoing the CALGB 9511 protocol at Walter Cantídio University Hospital (HUWC); to describe the impact of risk factors: presence of measurable residual disease, BCR-ABL fusion gene status, and allogeneic bone marrow transplant (BMT) on the survival of this group. Methodology: Retrospective evaluation of medical records of patients with ALL treated with this protocol between 2011 and 2022. Statistical analysis was performed using the Kaplan-Meier method to estimate survival probability. Results: 79 patients were eligible; 19% were BCR-ABL positive; the mean 2-year overall survival was 44%; The 2-year survival rate for patients undergoing HSCT was approximately 78%.. Conclusion: The survival curves of the study conducted at HUWC are similar to those described in the literature and corroborate the severity of the disease. Accessibility to new therapeutic modalities is a strategy that can improve the survival of these patients.

Author Biographies

Fernando Barroso Duarte

Supervisor. Head of the Hematology and Bone Marrow Transplant Service at Walter Cantídio University Hospital of UFC

Lívia Andrade Gurgel

Hematologist Physician in charge of the Hematology and Hemotherapy Service at Walter Cantídio University Hospital

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Published

05/12/2024

How to Cite

Mariano de Alencar, P. H., Barroso Duarte, F. ., Andrade Gurgel, L. ., Facundo de Alencar Araripe, L. ., Mota Segundo, H. A. ., & Magalhães Chaves , A. V. . (2024). Overall survival in patients with acute lymphoblastic leukemia treated with protocol CALGB 9511 at a tertiary hospital in the state of Ceará. JOURNAL OF BONE MARROW TRANSPLANTATION AND CELLULAR THERAPY, 5(1), 222. https://doi.org/10.46765/2675-374X.2024v5n1p222

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