EMERGING ACTIVITY OF CELLULAR IMMUNOTHERAPY FOR TREATMENT OF CANCER IN BRAZIL: REPORT FROM THE BRAZILIAN REGISTRY

Cinthya Corrêa  da Silva; Anderson  João Simione; Paula  Moreira da Silva Sabaini; Antonio  Vaz Macedo; Heliz Regina Alves das Neves; Monique  Ammi; Flavia  Ferreira da Costa; Valeria  Viana; Adriana  Mendes de Quadros Cavilha; Rosana  Rocha Concilio; Phillip  Scheinberg; Nelson  Hamerschlak; Marco Aurelio  Salvino; Adriana  Seber; Yana  Augusta Sarkis Novis; Vanderson  Geraldo Rocha; Joaquim  Gasparini dos Santos; Lucia  Mariano da Rocha Silla; Ricardo  Chiattone; Andreza Alice  Feitosa Ribeiro; Vaneuza  Araújo Moreira Funke; Leonardo  Javier Arcuri; Lucila  Nassif kerbauy; Jayr  Schmidt Filho; Carmem  Maria Sales Bonfim; Simone  Ojima Ferreira; Marcelo  Pasquini; Fernando  Barroso Duarte

doi:10.46765/2675-374X.2024v5n2p235

EMERGING ACTIVITY OF CELLULAR IMMUNOTHERAPY FOR TREATMENT OF CANCER IN BRAZIL

REPORT FROM THE BRAZILIAN REGISTRY

Authors

Cinthya Corrêa da Silva Hospital Israelita Albert Einstein, São Paulo, SP, https://orcid.org/0000-0002-8923-5062
Anderson João Simione Hospital Amaral Carvalho, Jaú, SP, https://orcid.org/0000-0002-6939-906X
Paula Moreira da Silva Sabaini Barretos Cancer Hospital, Barretos, SP, https://orcid.org/0000-0002-1359-7833
Antonio Vaz Macedo Hospital da Polícia Militar, Belo Horizonte, MG, https://orcid.org/0000-0002-7633-8839
Heliz Regina Alves das Neves Hospital de Clínicas – Universidade Federal do Paraná, Curitiba, PR; Hospital Nossa Senhora das Graças – Instituto Pasquini, Curitiba, PR, https://orcid.org/0000-0002-6717-0464
Monique Ammi Center for International Blood and Marrow Transplant Research (CIBMTR), Minneapolis, MN, USA,
Flavia Ferreira da Costa Hospital Samaritano Higienópolis, São Paulo, SP, https://orcid.org/0000-0003-2735-352X
Valeria Viana Hospital Universitário Clementino Fraga Filho, Univ. Fed. RJ, https://orcid.org/0009-0007-8637-8977
Adriana Mendes de Quadros Cavilha Real e Benemérita Sociedade de Beneficência Portuguesa de São Paulo, São Paulo, SP, https://orcid.org/0000-0001-9669-5297
Rosana Rocha Concilio https://orcid.org/0000-0001-6808-5598
Phillip Scheinberg Real e Benemérita Sociedade de Beneficência Portuguesa de São Paulo, São Paulo, SP, https://orcid.org/0000-0002-9047-4538
Nelson Hamerschlak Hospital Israelita Albert Einstein, São Paulo, SP, https://orcid.org/0000-0002-5140-5310
Marco Aurelio Salvino Universidade Federal da Bahia, Salvador, BA; Cell Therapy Researcher, ICO Barcelona; Hospital São Rafael, Salvador, BA https://orcid.org/0000-0001-5885-869X
Adriana Seber Hospital Samaritano Higienópolis, São Paulo, SP; Associação da Medula Óssea, São Paulo - AMEO , São Paulo, SP; Instituto de Oncologia Pediátrica, Graacc/Unifesp, São Paulo, SP https://orcid.org/0000-0003-4578-9423
Yana Augusta Sarkis Novis Sociedade Beneficente de Senhoras Hospital Sírio Libanês, São Paulo, SP, https://orcid.org/0000-0001-6590-069X
Vanderson Geraldo Rocha Hospital das Clínicas da Universidade de São Paulo, São Paulo, SP, https://orcid.org/0000-0003-0094-619X
Joaquim Gasparini dos Santos Hospital das Clínicas da Universidade de São Paulo, São Paulo, SP, https://orcid.org/0000-0001-6096-116X
Lucia Mariano da Rocha Silla Hospital de Clínicas de Porto Alegre, Porto Alegre, RS; Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, https://orcid.org/0000-0002-3892-6525
Ricardo Chiattone Hospital Samaritano Higienópolis, São Paulo, SP, https://orcid.org/0000-0001-7341-8502
Andreza Alice Feitosa Ribeiro Hospital Israelita Albert Einstein, São Paulo, SP,
Vaneuza Araújo Moreira Funke Hospital de Clínicas – Universidade Federal do Paraná, Curitiba, PR; Hospital Nossa Senhora das Graças – Instituto Pasquini, Curitiba, PR, https://orcid.org/0000-0002-2122-7277
Leonardo Javier Arcuri Hospital Israelita Albert Einstein, São Paulo, SP; Instituto Nacional do Câncer (INCA), Rio de Janeiro, RJ https://orcid.org/0000-0002-9673-1945
Lucila Nassif kerbauy Hospital Israelita Albert Einstein, São Paulo, SP, https://orcid.org/0000-0002-4441-9212
Jayr Schmidt Filho A.C. Camargo Cancer Center, São Paulo, SP, https://orcid.org/0000-0001-8212-1620
Carmem Maria Sales Bonfim Hospital Pequeno Príncipe – Curitiba, PR, https://orcid.org/0000-0003-0343-2610
Simone Ojima Ferreira Sociedade Beneficente de Senhoras Hospital Sírio Libanês, São Paulo, SP, https://orcid.org/0009-0001-3600-7007
Marcelo Pasquini Center for International Blood and Marrow Transplant Research (CIBMTR) and Medical College of Wisconsin, Milwaukee, WI, USA, https://orcid.org/0000-0003-1579-2293
Fernando Barroso Duarte Hospital Universitário Walter Cantídio, Fortaleza, CE https://orcid.org/0000-0001-5170-695X

DOI:

https://doi.org/10.46765/2675-374X.2024v5n2p235

Abstract

Chimeric antigen receptor T-cells (CAR T cells) are genetically modified cellular immunotherapies approved for standard of care treatment of patients with lymphoma and leukemia worldwide. Here we report the initial activity in Brazilian centers through the collaboration between the Brazilian Cellular Therapy and Bone Marrow Transplant Society (SBTMO) and Center for International Blood and Marrow Transplant Research (CIBMTR). A total of 38 patients who received CAR T cells between 2020 and 2023. The median age was 47 years (range 4-77). Indications include Non-Hodgkin Lymphoma (NHL; 26 cases; 68%), Acute Lymphoblastic Leukemia (ALL; 9 cases; 24%), and Multiple Myeloma (MM; 3 cases; 8%). 84% (75% - 24 NHL cases and 25% - 8 ALL cases) were commercial. This report demonstrates the initial implementation of CAR T cells in Brazil among centers that report to the SBTMO/CIBMTR. This infrastructure will assist in further capturing the activity, assessing the outcomes, and complying with regulatory requirements.

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07/24/2024

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da Silva, C. C. ., João Simione, A. ., Moreira da Silva Sabaini, P. ., Vaz Macedo, A. ., Heliz Regina Alves das Neves, Ammi , M. ., Ferreira da Costa, F. ., Viana, V. ., Mendes de Quadros Cavilha, A. ., Rocha Concilio, R. ., Scheinberg, P. ., Hamerschlak, N. ., Salvino, M. A. ., Seber , A. ., Augusta Sarkis Novis, Y. ., Geraldo Rocha, V. ., Gasparini dos Santos, J. ., Mariano da Rocha Silla, L. ., Chiattone, R. ., Feitosa Ribeiro, A. A. ., Araújo Moreira Funke, V. ., Javier Arcuri, L. ., Nassif kerbauy, L. ., Schmidt Filho, J. ., Maria Sales Bonfim, C. ., Ojima Ferreira, S. ., Pasquini, M., & Barroso Duarte, F. . (2024). EMERGING ACTIVITY OF CELLULAR IMMUNOTHERAPY FOR TREATMENT OF CANCER IN BRAZIL: REPORT FROM THE BRAZILIAN REGISTRY. JOURNAL OF BONE MARROW TRANSPLANTATION AND CELLULAR THERAPY, 5(2), 235. https://doi.org/10.46765/2675-374X.2024v5n2p235

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Vol. 5 No. 2 (2024): Journal of Bone Marrow Transplantation and Cellular Therapy

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Original article

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