RECOMMENDATIONS FOR SCREENING AND MANAGEMENT OF ENDOCRINOPATHIES AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION
DOI:
https://doi.org/10.46765/2675-374X.2023v4n1p196Keywords:
bone marrow transplantation, glucocorticoids, growth disorders, adrenal insufficiency, thyroid gland/radiation effects, graft vs host disease, gonads/drug effects, bone and bones/metabolism, adiposity, atherosclerosisAbstract
Endocrine disorders after hematopoietic stem cell transplantation result from the interaction between the underlying disease, host characteristics and treatment, including exposure to pre- and peri-transplant agents (chemotherapy and radiotherapy). In addition, post-transplantation factors, including graft-versus-host disease, and its treatment, especially glucocorticoids, also contribute to hormone deficiencies or endocrine disorders. Endocrinological alterations can be divided into six main groups: 1) Growth disorders; 2) Thyroid diseases; 3) Gonadal dysfunction; 4) Adrenal failure; 5) Osteometabolic disorders; 6) Obesity and metabolic syndrome. The purpose of this article is to update screening recommendations and management approaches for the various endocrine diseases, defining populations at risk, recommendations during follow-up, and treatment strategies, with attention to controversial issues.
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