Analysis of the profile and overall survival of patients submitted to total body irradiation as a form of conditioning for hematopoietic stem cell transplantation

Analysis of the profile and overall survival of patients submitted to total body irradiation as a form of conditioning for hematopoietic stem cell transplantation

Authors

  • Denise Ferreira Silva Alves Hospital Moinhos de Vento https://orcid.org/0000-0003-2770-8802
  • Alessandra Aparecida Paz
  • Paulo Renato Figueiredo Ferreira
  • Daniela Vargas Barletta
  • Bernardo Pinto Pinatti
  • Tiago Pereira Leão
  • Gunther Alex Schneider
  • Pedro Guilherme Schaefer
  • Lauro José Gregianin
  • Marta Nassif Pereira Lima
  • Liane Esteves Daudt

DOI:

https://doi.org/10.46765/2675-374X.2021v2n2p92

Keywords:

Total body irradiation (TBI), Hematopoietic Stem Cell Transplantation (HSCT), Acute effects, Late effects, Donor age, Donor sex, Graft versus host disease (GVHD).

Abstract

O trabalho é uma coorte retrospectiva com o intuito de analisar o perfil dos pacientes submetidos ao TMO no período de Janeiro de 2001 a Dezembro de 2016 que tiveram como parte do condicionamento o TBI. Foi realizado atraves da coleta de dados em prontuário transcritas para planilha Microsoft Excel 2010 e analisadas com o pacote estatístico SPSS versão 20.0. Foram avaliados 139 pacientes, sendo 92 (66,2%) do sexo feminino. Em relação ao tipo de TMO  51,8%  eram aparentados, 32,4% não-aparentados, 12,2%  haploidênticos e 3,6 % autólogos. O seguimento médio foi de 29,3 meses. As doenças mais frequentes foram LLA (73,4%) e LMA (8,6%). Noventa e sete pacientes foram classificados como doença avançada (70,8%) e 40 como precoce (29,2%), com taxa de sobrevida global, respectivamente de 31,8 e 62,4%. A dose mais utilizada no TBI foi 12Gy (78,4%). Cinquenta pacientes realizaram radioterapia prévia, sendo a mais comum de encéfalo total (74%). Os efeitos agudos predominantes foram neutropenia febril (60,4%) e mucosite G3-4 (41%) e os tardios alterações endocrinológicas (17,3%), osteonecrose (3,6%) e alterações cognitivas severas (2,9%). Quarenta e oito pacientes apresentaram DECH agudo  (34,5%) e 35 crônico (25,2%). A taxa de recaída global foi de 37,8%. A taxa de morte relacionada ao TMO foi de  34,6%. O trabalho permitiu inferir que o Hospital de Clinicas de Porto Aleggre apresenta taxas de recidiva, sobrevida global e complicações semelhante aos índices dos grandes centros mundiais.

Author Biography

Denise Ferreira Silva Alves, Hospital Moinhos de Vento

Médica Radio-Oncologista titular do departamento de Radioterapia e Radiocirurgia do Hospital Moinhos de Vento. Graduada em Medicina pela Pontifícia Universidade Católica do Rio Grande do Sul (2012). Especialização em Radioterapia no Hospital de Clínicas de Porto Alegre (2018). Titulo de especialista em Radioterapia pela sociedade brasileira de radioterapia (2019). Dedicação e especial interesse no tratamento do câncer de mama e neoplasias hematológicas. 

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Published

07/16/2021

How to Cite

Alves, D. F. S., Paz, A. A., Ferreira, P. R. F., Barletta, D. V., Pinatti, B. P., Leão, T. P., Schneider, G. A., Schaefer, P. G., Gregianin, L. J., Lima, M. N. P., & Daudt, L. E. (2021). Analysis of the profile and overall survival of patients submitted to total body irradiation as a form of conditioning for hematopoietic stem cell transplantation: Analysis of the profile and overall survival of patients submitted to total body irradiation as a form of conditioning for hematopoietic stem cell transplantation. JOURNAL OF BONE MARROW TRANSPLANTATION AND CELLULAR THERAPY, 2(2), p92. https://doi.org/10.46765/2675-374X.2021v2n2p92

Issue

Vol. 2 No. 2 (2021): Journal of Bone Marrow Transplantation and Cellular Therapy

Section

Original article

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