A RETROSPECTIVE STUDY OF MEDICATION-RELATED OSTEONECROSIS OF THE JAW IN MULTIPLE MYELOMA PATIENTS

Authors

DOI:

https://doi.org/10.46765/2675-374X.2023v4n3p209

Keywords:

Osteonecrosis, Tocopherols., Pentoxifylline, Multiple myeloma

Abstract

Background: Multiple myeloma is a malignant hematological neoplasm, whose treatment involves the use of bisphosphonates and monoclonal antibodies, which may be related to medication-related osteonecrosis.

Objective: The present study aims to verify the presence of medication-related osteonecrosis of the jaws in patients undergoing treatment for multiple myeloma who used chemotherapy associated or not with bisphosphonates and/or monoclonal antibodies. Beyond this, to trace the epidemiological profile of patients who developed medication-related osteonecrosis.

Methods: This 15-year retrospective observational study consisted of evaluating 461 medical records of patients diagnosed with multiple myeloma from the oncology referral hospital in Brazil, Erasto Gaertner Hospital.

Results: It was observed that both the group that developed osteonecrosis and the group that did not develop, no statistically significant difference when evaluated separately regarding sex, bone marrow transplant and ethnicity. However, the group with osteonecrosis showed a higher frequency in the use of bisphosphonates, did not progress to death, were non-smokers, the mandible was the most affected anatomical site, and the type of bone exposure spontaneously was the most observed.

Conclusions: The combined use of pentoxifylline and tocopherol was responsible for the successful resolution of cases of medication-related osteonecrosis. Isolating the underlying disease allowed for greater control and knowledge regarding the medications used for the treatment of medication-related osteonecrosis.

Author Biographies

Rafaela Savio Melzer, Pontifical Catholic University of Parana

DDS, Programa de Pós-graduação em Odontologia, Faculdade de Odontologia, Pontifícia Universidade Católica do Paraná, Curitiba, Brasil

Danielle Santos-Rodrigues, Universidade de São Paulo USP

MSc, Programa de Pós-graduação em Odontologia, Lasers in Dentistry.

Maria Isabela Guebur, Hospital Erasto Gaertner, Curitiba, Brazil

DDS, PhD, Membro do Serviço de Cirurgia Buco-Maxilo-Facial, Hospital Erasto Gaertner, Curitiba, Brazil

Laurindo Moacir Sassi, Hospital Erasto Gaertner, Curitiba, Brazil

DDS, PhD, Chefe do Serviço de Cirurgia Buco-Maxilo-Facial, Hospital Erasto Gaertner, Curitiba, Brazil

Sérgio Aparecido Ignácio, Pontifícia Universidade Católica do Paraná, Curitiba, Brasil

DDS, PhD, Professor Adjunto, Faculdade de Odontologia, Pontifícia Universidade Católica do Paraná, Curitiba, Brasil

Aline Cristina Batista Rodrigues Johann, Pontifícia Universidade Católica do Paraná, Curitiba, Brasil

DDS, PhD, Professora Adjunta, Faculdade de Odontologia, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil

Downloads

Published

12/27/2023

How to Cite

Savio Melzer, R., Santos-Rodrigues, D. ., Guebur, M. I. ., Sassi, L. M. ., Ignácio, S. A. ., & Batista Rodrigues Johann, A. C. . (2023). A RETROSPECTIVE STUDY OF MEDICATION-RELATED OSTEONECROSIS OF THE JAW IN MULTIPLE MYELOMA PATIENTS. JOURNAL OF BONE MARROW TRANSPLANTATION AND CELLULAR THERAPY, 4(3), 209. https://doi.org/10.46765/2675-374X.2023v4n3p209

Issue

Vol. 4 No. 3 (2023): Journal of Bone Marrow Transplantation and Cellular Therapy

Section

Original article

License

Copyright (c) 2023 JOURNAL OF BONE MARROW TRANSPLANTATION AND CELLULAR THERAPY

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

License and Copyright Policy

The Journal of Bone Marrow Transplantation and Cellular Therapy (JBMTCT) adopts an open access policy, ensuring that all published articles are freely available to the public without restrictions.

  1. License

    • All articles published in JBMTCT are licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
    • This license permits anyone to:
      • Share: Copy and redistribute the material in any medium or format.
      • Adapt: Remix, transform, and build upon the material for any purpose, even commercially.
    • The only requirement is that appropriate credit is given to the original authors and source, a link to the license is provided, and any changes made are indicated.

    More information about the license can be found here: Creative Commons Attribution 4.0 International License.

  2. Authors’ Rights

    • Authors retain the copyright to their work.
    • Authors grant JBMTCT the right to publish the work and make it openly accessible online.
    • Authors are free to:
      • Distribute the published version of their article (e.g., post it on personal websites or institutional repositories).
      • Use the article in future works, presentations, or derivative publications, as long as the original publication in JBMTCT is properly acknowledged.

  3. No Embargo

    • There is no embargo period; articles are made freely available immediately upon publication.

  4. Ethical Use

    • Users of JBMTCT articles must ensure proper citation of the authors and the journal.
    • Articles must not be used in ways that violate ethical or legal standards.

  5. Disclaimer

    • While JBMTCT aims to ensure the accuracy and reliability of published content, the journal and its editors are not responsible for the consequences of its use.

For any questions regarding our licensing terms, please contact us at: journalbmtct@sbtmo.org.br 

JBMTCT is committed to the principles of open access to advance knowledge and scientific collaboration.