EVALUATION OF PREDICTABILITY OF BONE MARROW CELL CELLULARITY FROM RELATED AND UNRELATED DONORS

Authors

  • Simone Pereira Lermontov Instituto Nacional de Câncer José Alencar Gomes da Silva - INCA
  • Cecilia Ferreira da Silva Borges
  • Simone Maradei Pereira
  • Marta Colares Nogueira
  • Luís Fernando da Silva Bouzas Instituto Nacional de Câncer – INCA https://orcid.org/0000-0002-6267-9448
  • Simone Carreiro Brasil
  • Cláudia Valeria Ramos Ribeiro
  • Karen Wagner de Souza
  • Pedro Felipe Couto Vieira
  • Carla Cristina Pedrosa de Lira de Morais
  • Leonardo Javier Arcuri

DOI:

https://doi.org/10.46765/2675-374X.2022v3n2p164

Keywords:

Hematopoietic Stem Cell Transplantation; Bone Marrow Harvest; Donors.

Abstract

Introduction: For successful hematopoietic stem cell transplantation, a minimum number of total nucleated cells should be obtained (TNC) during the bone marrow (BM) harvest procedure. Objectives: Evaluate the predictability of the BM TNC collected from an interim sample collected during the procedure and the factors related to high-cellular harvest. Methodology: This is a retrospective observational study including BM donors and recipient from 2017 to 2019. The final TNC was based on an interim quantification of TNC and was compared with the actual final TNC obtained. Results: 81 donors were included and interim TNC of 53 donors were available. Based on linear regression, a significant correlation was found between the volume of BM collected and the interim and final TNC (n=53; R2=0.83; P<0.001). The relationship between donor and recipient weight significantly influenced the collection yield. There was also a positive correlation between the volume of BM collected and the interim and final count of TNC (n=53; r=0.88; p<0.001). The difference in donor and recipient weight also had a positive correlation (p<0.02). Conclusion: Our results showed that interim TNC quantification can help to achieve a better performance during the procedure, allowing real-time re-estimation of the volume needed to be harvested. 

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Published

11/23/2022

How to Cite

Pereira Lermontov, S., Ferreira da Silva Borges, C. ., Maradei Pereira, S., Colares Nogueira, M., Bouzas, L. F. da S. ., Carreiro Brasil, S., Ramos Ribeiro, C. V., Wagner de Souza, K. ., Felipe Couto Vieira, P., Pedrosa de Lira de Morais, C. C., & Javier Arcuri, L. (2022). EVALUATION OF PREDICTABILITY OF BONE MARROW CELL CELLULARITY FROM RELATED AND UNRELATED DONORS. JOURNAL OF BONE MARROW TRANSPLANTATION AND CELLULAR THERAPY, 3(2), 164. https://doi.org/10.46765/2675-374X.2022v3n2p164

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