Autologous Hematopoietic Stem Cell Transplantation is an Effective Treatment Option in Early Relapsed and Primary Refractory Diffuse Large B-Cell Lymphoma.

British Hospital Transplant Unit

Authors

  • Ana Oliver Unidad de Trasplante de Progenitores Hematopoyéticos, Hospital Británico. Montevideo. https://orcid.org/0000-0002-7782-2024
  • Eloisa Riva Unidad de Trasplante de Progenitores Hematopoyéticos, Hospital Británico. Montevideo. https://orcid.org/0000-0002-4750-034X
  • Victoria Irigoin Unidad de Trasplante de Progenitores Hematopoyéticos, Hospital Británico. Montevideo.
  • Sebastian Galeano Unidad de Trasplante de Progenitores Hematopoyéticos, Hospital Británico. Montevideo.
  • Silvia Pierri Unidad de Trasplante de Progenitores Hematopoyéticos, Hospital Británico. Montevideo.
  • Laura Bello Unidad de Trasplante de Progenitores Hematopoyéticos, Hospital Británico. Montevideo.
  • Virginia Marcalain Unidad de Trasplante de Progenitores Hematopoyéticos, Hospital Británico. Montevideo.
  • Regis Gai Unidad de Trasplante de Progenitores Hematopoyéticos, Hospital Británico. Montevideo.
  • Pablo Muxi Unidad de Trasplante de Progenitores Hematopoyéticos, Hospital Británico. Montevideo.

DOI:

https://doi.org/10.46765/2675-374X.2023v4n2p186

Keywords:

Autologous Stem Cell Transplantation, Diffuse Large B-cell Lymphoma, Primary Refractory

Abstract

Introduction: 10-15% of diffuse large B-cell lymphomas (DLBCL) patients fail to achieve complete response (CR) after R-CHOP, and are considered primary refractory. There is limited transplant data  in this population.

Objetive: to evaluate the outcomes of primary refractory DLBCL patients transplanted at our center.

Results: we evaluated 34 R/R patients treated with R-CHOP as first line. After second line, 30.4% of primary refractory/early relapse achieved CR, and 88.2% did so after ASCT. Median follow-up: 56.1 months, median OS was not reached; the estimated 5-year OS was 61.7%. Median OS of late relapse (Group 1) was not reached, and was 52 months for primary refractory/early relapse (Group 2) (p=0.023). The 5-year OS was 87.5% in Group 1 vs 49% in Group 2 (p=0.023).

Conclusions: Primary refractory and early relapsed DLBCL undergoing second-line therapy and ASCT have worse OS compared to late relapse. However, 49% of primary refractory patients who proceeded to ASCT had prolonged survival, which supports the role of ASCT in this population.

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Published

05/31/2023

How to Cite

Ana Oliver, Riva, E., Irigoin, V., Galeano, S., Pierri, S., Bello, L., Marcalain, V., Gai, R., & Muxi, P. (2023). Autologous Hematopoietic Stem Cell Transplantation is an Effective Treatment Option in Early Relapsed and Primary Refractory Diffuse Large B-Cell Lymphoma.: British Hospital Transplant Unit. JOURNAL OF BONE MARROW TRANSPLANTATION AND CELLULAR THERAPY, 4(2), 186. https://doi.org/10.46765/2675-374X.2023v4n2p186

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