CITOKINE RELEASE SYNDROME MANAGEMENT IN ADULTS AND PEDIATRIC PATIENTS
DOI:
https://doi.org/10.46765/2675-374X.2022v3n2p163Keywords:
cytokine release syndrome. CRS. CAR T complications. Anti IL 6. Tocilizumab. Toxicity.Abstract
Chimeric Antigen Receptor (CAR) T cell therapy has demonstrated efficacy in B cell malignances. However, the treatment is not harmless and, in some patients, can lead to a fatal endpoint. For this reason, the knowledge and the early recognition and management of the side effects related to CAR-T cell therapy for the multidisciplinary team is essential. In this article, we have summarized the current recommendations for identification, gradation and management of cytokine release syndrome related to CAR-T cell therapy.
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