TY - JOUR AU - Novaes, Cristina de Paula AU - Hallack Neto, Abrahão Elias AU - Santos, Kelli Borges dos AU - Corrêa, Luciana PY - 2021/07/16 Y2 - 2024/03/29 TI - Impact of LEAM and CBV conditioning on gastrointestinal toxicity at early periods following hematopoietic cell transplantation: A retrospective study: Gastrointestinal toxicity after LEAM and CBV JF - JOURNAL OF BONE MARROW TRANSPLANTATION AND CELLULAR THERAPY JA - jbmtct VL - 2 IS - 2 SE - Original article DO - 10.46765/2675-374X.2021v2n2p51 UR - https://www.jbmtct.com.br/seer/index.php/jbmtct/article/view/51 SP - p51 AB - <p><strong>Objectives</strong>: To compare the severity of oral mucositis and the frequency of gastrointestinal mucositis, and to observe if there is impact of these adverse effects on overall survival (OS), in patients who underwent CBV (carmustine, BCNU, and VP-16) and LEAM (lomustine, etoposide, Ara-C, and melphalan) conditioning for autologous hematopoietic cell transplantation (aHCT). <strong>Method</strong>: We collected retrospective data from medical records (<em>n</em> = 120) of transplantation and mucositis in the digestive tract of Hodgkin’s and non-Hodgkin’s lymphoma patients. <strong>Results</strong>: The frequency of OM grade 1 was higher in LEAM (36.76%) than in CBV (19.72%, <em>p</em>=0.038). There were no significant differences between the frequency of gastrointestinal mucositis in the two regimens (CBV - 52.11% and LEAM - 63.27%, <em>p</em>=0.305). CBV regimen exhibited lower 1-year overall survival (OS) than did LEAM (<em>p</em>=0.003). Oral mucositis grade ≥2 was associated with reduced OS in the CBV group (<em>p</em>=0.013). CBV regimen (HR=2.98, <em>p</em> 0.005) and oral mucositis grade ≥2 (HR=2.17, <em>p</em>=0.013) interfered negatively on the OS rate. <strong>Conclusion</strong>: Oral mucositis was more severe in CBV than in LEAM, decreasing the OS rate. Further studies with comprehensive follow-up and toxicity analyses must be undertaken to clarify the safety of LEAM conditioning in the digestive tract.</p> ER -